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-Automatic translation

Women who undergo hysterectomy where the indication for the procedure is premalignant cancer or where the post-operative diagnosis is precancerous changes in the cervix are at increased risk of vaginal intraepithelial neoplasia, VaIN, and invasive vaginal disease.

The follow-up should be based on clinical assessment but the following is a guideline:

Post-hysterectomy tissue analysis shows that precancerous changes are completely removed, surgical edges clean

  • Vaginal sample for HPV - 6 months after surgery

    • hr-HPV negative

      • No further follow-up

    • h-HPV positive

      • Referral to colposcopy

        • If no signs of VaIN, follow-up is stopped.

Post-hysterectomy tissue analysis shows that precancerous changes are not completely removed, surgical edges are not clean

  • CIN 1 tissue analysis

    • Vaginal sample for HPV 6, 12, and 24 months after surgery

      • h-HPV positive

        • Referral to colposcopy

      • Hr-HPV negative

        • Follow-up is stopped after 24 months

  • CIN 2-3 tissue analysis

    • Vaginal sample for HPV 6, 12 months after surgery

    • Vaginal sample for HPV every year for the next 9 years

    • Follow-up should be until the age of 65 or at least 10 years after the surgery

    • h-HPV positive

      • Referral to colposcopy